Adiporon 是一种新型的口服作用于脂联素受体的激动剂，针对脂联素受体1和脂联素受体2的KD分别为1.8 和 3.1 μM。
AdipoRon attenuates Ang II-induced vascular injury. (A) Immunofluorescence analysis of p-p38 and quantification of its protein expression levels, in Sham, Ang II and Ang II+ AdipoRon-treated mice (scale bar, 100 µm). Representative images of (B) Sirius Red (scale bar, 200 µm) and (C) hematoxylin and eosin staining (scale bar, 50 µM) of aorta cross sections from sham, Ang II and Ang II+ AdipoRon-treated mice. Data are expressed as the mean ± standard deviation (n=5). *P<0.05 vs. sham, #P<0.05 vs. Ang II. Ang II, angiotensin; p-p38, phosphorylated-p38
Schisandrin A (Sch A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.