DYRK

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S7338 AZ191 <1 mg/mL 85 mg/mL 1 mg/mL
S7327 ID-8 <1 mg/mL 60 mg/mL 2 mg/mL
S3817 Harmine hydrochloride -1 mg/mL 21 mg/mL -1 mg/mL
产品目录 产品描述 文献引用 实验数据
S7338

AZ191

AZ191是一种有效的选择性DYRK1B抑制剂,无细胞试验中IC50为17 nM,比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。

S7327

ID-8

ID-8能够在长期培养中维持胚胎干细胞自我更新。

S3817New

Harmine hydrochloride

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).