5HT2C Receptor Rabbit Recombinant mAb

目录号：A5414

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生物描述

特异性 5HT2C Receptor Rabbit Recombinant mAb detects endogenous level of total 5HT2C Receptor.
背景 The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to Gq/G11 and mediate excitatory neurotransmission, including 5-HT2A, 5-HT2B, and 5-HT2C. 5-HT2C receptors are located mainly in the choroid plexus, and in rats is also found in many other brain regions in high concentrations, including parts of the hippocampus, anterior olfactory nucleus, substantia nigra, several brainstem nuclei, amygdala, subthalamic nucleus and lateral habenula. 5-HT2C receptors are also found on epithelial cells lining the ventricles. 5-HT2C receptors are claimed to significantly regulate mood, anxiety, feeding, and reproductive behavior. It regulates dopamine release in the striatum, prefrontal cortex, nucleus accumbens, hippocampus, hypothalamus, and amygdala, among others.

使用信息

抗体应用 WB,ELISA,ELISA
稀释比例
WB
1:1000
反应性 Human Mouse Rat
MW (kDa) 52kDa
抗体类型 Rabbit
储存液配方 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件
(自收到货起)		 Store at –20°C.

Application Data

WB

Validated by Selleck