Barasertib (AZD1152-HQPA)

目录号：S1147 批次号：S114707

打印

化学数据

化学结构式 别名 AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C26H30FN7O3
分子量 507.56 CAS号 722544-51-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (197.02 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) 是一种高度选择性的Aurora B抑制剂，无细胞试验中IC50为0.37 nM，作用于Aurora B比作用于Aurora A选择性高3700倍左右。
靶点
Aurora B [1]
(Cell-free assay)
0.37 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by Nature, 2014, 508(7494), 118-22]

数据来源于[Data independently produced by J Exp Med, 2014, 10.1084/jem.20141123]

数据来源于[, 33, 3550-60]

数据来源于[, 31, 1217–1227]

Barasertib (AZD1152-HQPA)在文献中得到引用

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3] PubMed: 38262581
Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041] PubMed: 38310113
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells [ Br J Cancer, 2024, 10.1038/s41416-024-02584-z] PubMed: 38287178
Chromosomal passenger complex condensates generate parallel microtubule bundles in vitro [ J Biol Chem, 2024, S0021-9258(24)00045-0] PubMed: 38272221
Inhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions [ Sci Rep, 2024, 14(1):4303] PubMed: 38383756
Molecular landscape and functional characterization of centrosome amplification in ovarian cancer [ Nat Commun, 2023, 14(1):6505] PubMed: 37845213
Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis [ Nat Commun, 2023, 14(1):1680] PubMed: 36973261
Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502] PubMed: 37021526
Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502] PubMed: 37021526
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment [ Cell Rep, 2023, 42(9):113098] PubMed: 37714156

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。

5. 对于合理的退换货要求，我们会在5个工作日内处理完成您的款项退还和新换货物的运输等，请耐心等待。