DHA (Dihydroartemisinin)

目录号：S2290 批次号：S229006

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化学数据

化学结构式 别名 Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C15H24O5
分子量 284.35 CAS号 71939-50-9
Solubility (25°C)* 体外 DMSO 56 mg/mL (196.94 mM)
Ethanol 26 mg/mL (91.43 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 DHA (Dihydroartemisinin)是一种Artemisinin 的半合成衍生物，从传统中药Artemisia annua分离而来的。Dihydroartemisinin 可通过抑制 NF-κB 激活来诱导自噬和凋亡。
靶点
NF-κB [4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

, Oncotarget, 2015, 6(7):5275-91.

, J Exp Clin Cancer Res, 2017, 36(1):68

, PLoS One, 2015, 10(3):e0120426.

数据来源于[Data independently produced by , , Biochem Pharmacol, 2018, 150:72-85]

DHA (Dihydroartemisinin)在文献中得到引用

A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets [ ACS Infect Dis, 2024, 10.1021/acsinfecdis.3c00588] PubMed: 38499199
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways [ Neoplasia, 2024, 51:100991] PubMed: 38507887
Protocol for analysis of intracellular conversion of artezomib molecules into new proteasome inhibitors in Plasmodium falciparum parasites [ STAR Protoc, 2024, 5(1):102896] PubMed: 38363687
Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma [ J Exp Clin Cancer Res, 2023, 42(1):251] PubMed: 37759291
Micromolar Dihydroartemisinin Concentrations Elicit Lipoperoxidation in Plasmodium falciparum-Infected Erythrocytes [ Antioxidants (Basel), 2023, 12(7)1468] PubMed: 37508006
Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein [ Cell Death Discov, 2023, 9(1):97] PubMed: 36928207
Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA) [ Front Pharmacol, 2023, 14:1220796] PubMed: 37649890
Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA) [ Front Pharmacol, 2023, 14:1220796] PubMed: 37649890
Dihydroartemisinin Potentiates VEGFR-TKIs Antitumorigenic Effect on Osteosarcoma by Regulating Loxl2/VEGFA Expression and Lipid Metabolism Pathway [ J Cancer, 2023, 14(5):809-820] PubMed: 37056396
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin [ Nat Commun, 2022, 13-1:5746] PubMed: 36180431

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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