Mercaptopurine (6-MP)

目录号:S1305 批次号:S130503

打印

化学数据

化学结构式 别名 6-MP 储存条件
(自收到货起)
3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C5H4N4S

分子量 152.18 CAS号 50-44-2
Solubility (25°C)* 体外 DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Mercaptopurine (6-MP)是一种广泛应用于治疗白血病的药物,也是一种免疫抑制药,通过整合巯基嘌呤的甲基转移酶代谢产物进入DNA和RNA抑制新创嘌呤合成。
靶点
PRPP Amidotransferase [2]
体外研究

Mercaptopurine被广泛用于治疗恶性肿瘤,风湿性疾病,皮肤病,炎症性肠道疾病,以及实体器官移植排斥。[1] Mercaptopurine通过抑制磷酸核糖焦磷酸酰胺转移酶(PRPP酰胺转移酶)而抑制嘌呤核苷和代谢。PRPP酰胺转移酶是嘌呤合成的限速酶。它会改变RNA和DNA的合成和功能。Mercaptopurine干扰核苷酸的互变和糖蛋白的合成。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Mercaptopurine (6-MP)在文献中得到引用

Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [ Nat Commun, 2023, 14(1):5913] PubMed: 37737247
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [ Nat Commun, 2023, 14(1):5913] PubMed: 37737247
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y] PubMed: 35118583
Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro [ Biochem Biophys Res Commun, 2022, 638:103-111] PubMed: 36442232
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis [ Theranostics, 2021, 11(9):4011-4029] PubMed: 33754045
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma [ Hum Cell, 2021, 34(6):1911-1918] PubMed: 34383271
Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00639-4] PubMed: 34731453
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00579-z] PubMed: 34304386
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. [ Cancer Cell Int, 2020, 19;20:58] PubMed: 32099531

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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