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别名 | 6-MP | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C5H4N4S |
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分子量 | 152.18 | CAS号 | 50-44-2 | |
Solubility (25°C)* | 体外 | DMSO | 30 mg/mL (197.13 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Mercaptopurine (6-MP)是一种广泛应用于治疗白血病的药物,也是一种免疫抑制药,通过整合巯基嘌呤的甲基转移酶代谢产物进入DNA和RNA抑制新创嘌呤合成。 | |
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体外研究 | Mercaptopurine被广泛用于治疗恶性肿瘤,风湿性疾病,皮肤病,炎症性肠道疾病,以及实体器官移植排斥。[1] Mercaptopurine通过抑制磷酸核糖焦磷酸酰胺转移酶(PRPP酰胺转移酶)而抑制嘌呤核苷和代谢。PRPP酰胺转移酶是嘌呤合成的限速酶。它会改变RNA和DNA的合成和功能。Mercaptopurine干扰核苷酸的互变和糖蛋白的合成。[2] |
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Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [ Nat Commun, 2023, 14(1):5913] | PubMed: 37737247 |
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [ Nat Commun, 2023, 14(1):5913] | PubMed: 37737247 |
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] | PubMed: 35207746 |
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y] | PubMed: 35118583 |
Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro [ Biochem Biophys Res Commun, 2022, 638:103-111] | PubMed: 36442232 |
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis [ Theranostics, 2021, 11(9):4011-4029] | PubMed: 33754045 |
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma [ Hum Cell, 2021, 34(6):1911-1918] | PubMed: 34383271 |
Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00639-4] | PubMed: 34731453 |
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00579-z] | PubMed: 34304386 |
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. [ Cancer Cell Int, 2020, 19;20:58] | PubMed: 32099531 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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