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别名 | NSC-113926 | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C43H58N4O12 |
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分子量 | 822.94 | CAS号 | 13292-46-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (121.51 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Rifampin (Rifampicin)是DNA依赖性的RNA聚合酶抑制剂,用于治疗许多细菌感染案例。 | |
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体外研究 | Rifampicin抑制IκBα降解和mitogen活化蛋白激酶(MAPK)磷酸化。Rifampicin以Rifampicin和MD-2浓度依赖性结合人的MD-2。在蓝色的hTLR4的293细胞和免疫microgial BV-2细胞中,Rifampicin以剂量依赖的方式抑制LPS(20 ng/mL)诱导的NF-κB活化,IC 50为44.1 μM。Rifampicin(50 μM)在不同的LPS的剂量抑制NF-κB活化,促进LPS诱导的NF-κB水平的最大化。在BV-2细胞中,Rifampicin抑制LPS (200 ng/mL)诱导的NO的产生,IC 50为21.2 μM。在胶质BV-2和RAW264.7巨噬细胞中,Rifampicin抑制LPS诱导的TNF-α和IL-1β的产生。Rifampicin抑制先天免疫信号是不依赖于孕烷X受体NR1I2的。[1] Rifampicin结合聚酯血管prostheses(PVP)官能化cyclodextrin (PVP-CD)导致细菌粘附显著减少以及对革兰氏阳性菌的生长抑制。[2] Rifampicin(50 μg/mL)显著降低固定相培养物的CFU计数,并减少对数相培养的CFU计数到零。Rifampicin特别合适,因为它是杀菌并开始作用的一个小时内杀死M. tuberculosis。[3] |
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TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs [ Cell Death Dis, 2023, 14(1):64] | PubMed: 36707511 |
Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity [ Int J Mol Sci, 2022, 23(13)7383] | PubMed: 35806386 |
SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System [ Biomedicines, 2021, 9(8)996] | PubMed: 34440200 |
MDM2 Binding Protein Induces the Resistance of Hepatocellular Carcinoma Cells to Molecular Targeting Agents via Enhancing the Transcription Factor Activity of the Pregnane X Receptor [ Front Oncol, 2021, 11:715193] | PubMed: 34249768 |
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model [ PLoS One, 2021, 16(11):e0260633] | PubMed: 34847172 |
Identification of Small-Molecule Inhibitors of Brucella Diaminopimelate Decarboxylase by Using a High-Throughput Screening Assay. [ Front Microbiol, 2020, 10:2936] | PubMed: 32038511 |
A methylation functional detection hepatic cell system validates correlation between DNA methylation and drug-induced liver injury. [ Pharmacogenomics J, 2020, 10.1038/s41397-020-0160-7] | PubMed: 32029904 |
Enniatin A1, A Natural Compound with Bactericidal Activity against Mycobacterium tuberculosis In Vitro. [ Molecules, 2019, 25(1)] | PubMed: 31861925 |
TLR9 rs352139 Genetic Variant Promotes Tacrolimus Elimination in Chinese Liver Transplant Patients During the Early Posttransplantation Period. [ Pharmacotherapy, 2019, 39(1):67-76] | PubMed: 30537010 |
Human PXR-mediated transcriptional activation of CYP3A4 by 'Fuzi' extracts. [ Toxicol Mech Methods, 2019, 29(3):155-164] | PubMed: 30303438 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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