生物描述

特异性

ACE1 Rabbit Recombinant mAb detects endogenous levels of total ACE1.

背景

Angiotensin-converting enzyme 1 (ACE1, also known as kininase II) is a zinc-dependent dicarboxypeptidase with two catalytic domains that plays a major part in blood pressure regulation by converting angiotensin I to angiotensin II. It is a novel marker for identifying hemangioblasts differentiating from human embryonic stem cells (hESC). ACE cleaves many peptides besides angiotensin I and thereby affects diverse physiological functions, including renal development and male reproduction. In addition, ACE has a role in both innate and adaptive responses by modulating macrophage and neutrophil function. ACE also affects the display of major histocompatibility complex (MHC) class I and MHC class II peptides, potentially by enzymatically trimming these peptides.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse
MW (kDa)	195kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Bernstein KE, et al. Nat Rev Nephrol. 2018, 14(5):325-336. [2] Zambidis ET, et al. Blood. 2008, 112(9):3601-14.

Application Data

WB

IHC