ACSS2 inhibitor

目录号：S8588 批次号：S858803

打印

化学数据

别名

Ac-CoA Synthase Inhibitor1

储存条件
(自收到货起)

3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂

化学式

C₂₀H₁₈N₄O₂S₂

分子量

410.51

CAS号

508186-14-9

Solubility (25°C)*

体外

DMSO

82 mg/mL (199.75 mM)

Ethanol

5 mg/mL (12.17 mM)

Water

Insoluble

体内（现配现用）

澄清溶液	5% DMSO 1 40% PEG 300 2 55%ddH2O	1.25mg/ml (3.04mM)	以 1 mL 工作液为例,取50 μL 25mg/ml的澄清DMSO储备液加到400 μL PEG300中,混合均匀使其澄清;向上述体系中加入550 μL ddH2O定容至1mL。工作液请现配现用!
澄清溶液	5%DMSO 1 Corn oil	1.03mg/ml (2.51mM)	以 1 mL 工作液为例，取50μL20.5mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。

靶点

ACSS2 ^[1]
(Cell-free assay)

~0.6 μM

体外研究

ACSS2 inhibitor抑制HepG2细胞将[14C]acetate整合入脂质中，IC50为6.8 μM。它能够抑制HepG2细胞利用[14C]acetate进行组蛋白乙酰化，IC50为5.5 μM^[1]。

参考文献

ACSS2 inhibitor在文献中得到引用

Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence [ Nat Commun, 2024, 15(1):3200]	PubMed: 38615014
Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway [ Cell Commun Signal, 2024, 22(1):187]	PubMed: 38515158
Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation [ Ecotoxicol Environ Saf, 2024, 270:115877]	PubMed: 38150747
Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation [ Cell Rep, 2023, 42(6):112583]	PubMed: 37267106
Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy [ JCI Insight, 2023, 10.1172/jci.insight.165817]	PubMed: 37870960
Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids [ Cell Rep, 2022, 39(9):110870]	PubMed: 35649368
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells [ Elife, 2022, 11e75908]	PubMed: 36052997
ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages [ Biochim Biophys Acta Mol Basis Dis, 2022, 1868(10):166458]	PubMed: 35700791
Metabolic Adaptation as Potential Target in Papillary Renal Cell Carcinomas Based on Their In Situ Metabolic Characteristics [ Int J Mol Sci, 2022, 23(18)10587]	PubMed: 36142502
Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells [ Transl Oncol, 2022, 19:101386]	PubMed: 35263700

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。