AKT1/2 Rabbit Recombinant mAb

生物描述

特异性

AKT1/2 Rabbit Recombinant mAb detects endogenous level of total AKT1/2.

背景

AKT, a serine/threonine protein kinase, also known as protein kinase B and a member of AGC family, regulates a variety of cellular processes including survival, proliferation, protein translation and metabolism. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport. Akt regulate cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins, master lysosomal regulator TFEB and murine double minute 2 (MDM2).

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	56kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Michael J. Zinda, et al. Clinical Cancer Research. 2001, 7(8).

Application Data

WB

IHC