Datasheet

生物描述

特异性	Alpha Sarcoglycan Rabbit Recombinant mAb detects endogenous levels of total Alpha Sarcoglycan.
背景	In skeletal muscle, the dystrophin-associated glycoprotein complex forms a link between the actin cytoskeleton and the extracellular matrix that is critical for muscle integrity. Within this complex resides the sarcoglycan subcomplex, which consists of four transmembrane glycoproteins (alpha-, beta-, gamma-, and delta-sarcoglycan). During assembly, beta-sarcoglycan tightly associates with delta-sarcoglycan to form a functional core that then recruits gamma- and alpha-sarcoglycan to form the sarcoglycan complex. Together with sarcospan, the sarcoglycan complex binds other components of the dystrophin-associated glycoprotein complex and integrates into the myofibre’s membrane. Once integrated, the sarcoglycan complex plays a pivotal role in mechanically stabilising the sarcolemma as well as the dystrophin-associated glycoprotein complex. Additionally, the sarcoglycan complex undergoes chemical modifications in response to muscle contractions, thereby transducing mechanical information into a cellular signal. The sarcoglycans are a group of transmembrane glycoproteins with a large extracellular and a short intracellular domain. In skeletal and cardiac muscle, the sarcoglycan complex is comprised of four subunits at an equal stoichiometric ratio: α-, β-, γ-, and δ-sarcoglycan. In smooth muscle, ε- and ζ-sarcoglycan are incorporated into the sarcoglycan complex and replace α- and γ-sarcoglycan, respectively. α-sarcoglycan may be an important factor for the differentiation of myofibres.

特异性

Alpha Sarcoglycan Rabbit Recombinant mAb detects endogenous levels of total Alpha Sarcoglycan.

背景

In skeletal muscle, the dystrophin-associated glycoprotein complex forms a link between the actin cytoskeleton and the extracellular matrix that is critical for muscle integrity. Within this complex resides the sarcoglycan subcomplex, which consists of four transmembrane glycoproteins (alpha-, beta-, gamma-, and delta-sarcoglycan). During assembly, beta-sarcoglycan tightly associates with delta-sarcoglycan to form a functional core that then recruits gamma- and alpha-sarcoglycan to form the sarcoglycan complex. Together with sarcospan, the sarcoglycan complex binds other components of the dystrophin-associated glycoprotein complex and integrates into the myofibre’s membrane. Once integrated, the sarcoglycan complex plays a pivotal role in mechanically stabilising the sarcolemma as well as the dystrophin-associated glycoprotein complex. Additionally, the sarcoglycan complex undergoes chemical modifications in response to muscle contractions, thereby transducing mechanical information into a cellular signal. The sarcoglycans are a group of transmembrane glycoproteins with a large extracellular and a short intracellular domain. In skeletal and cardiac muscle, the sarcoglycan complex is comprised of four subunits at an equal stoichiometric ratio: α-, β-, γ-, and δ-sarcoglycan. In smooth muscle, ε- and ζ-sarcoglycan are incorporated into the sarcoglycan complex and replace α- and γ-sarcoglycan, respectively. α-sarcoglycan may be an important factor for the differentiation of myofibres.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

50kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Tarakci H, et al. Front Biosci (Landmark Ed). 2016, 21:744-56.

Application Data

WB

Validated by Selleck