AOA (Aminooxyacetic acid) hemihydrochloride

目录号：S4989 批次号：S498902

化学数据

	别名	Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, Aminooxyacetate hemihydrochloride	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂H₅NO₃._1/2HCl
	分子量	109.3	CAS号	2921-14-4
Solubility (25°C)*	体外	DMSO	21 mg/mL (192.13 mM)
		Water	21 mg/mL (192.13 mM)
		Ethanol	21 mg/mL (192.13 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

AOA (Aminooxyacetic acid) hemihydrochloride 是氨基丁酸转氨酶（aminobutyrate aminotransferase）抑制剂，参与氨基酸和聚胺代谢。AOA hemihydrochloride也是一种 CBS (cystathionine β-synthase) 抑制剂。

靶点

GABA-T ^[1]

Malate-aspartate shuttle ^[1]

参考文献

AOA (Aminooxyacetic acid) hemihydrochloride在文献中得到引用

NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells [ Research Square, 2024, 10.21203/rs.3.rs-3849836/v1]	PubMed: none
Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage [ Cell Rep Med, 2023, 4(5):101026]	PubMed: 37137303
Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis [ EMBO Mol Med, 2023, e15674.]	PubMed: 36855912
The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment [ Cell Death Dis, 2023, 14(11):784]	PubMed: 38036520
L-cystathionine protects against oxidative stress and DNA damage induced by oxidized low-density lipoprotein in THP-1-derived macrophages [ Front Pharmacol, 2023, 14:1161542]	PubMed: 37560474
Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury [ Biomolecules, 2022, 12(5)728]	PubMed: 35625656
Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation [ J Cancer, 2022, 13(3):1061-1072]	PubMed: 35154470
Yap-Myc signaling induces pancreatic stellate cell activation through regulating glutaminolysis [ Exp Cell Res, 2022, 411(1):113000]	PubMed: 34958764
Mistimed H 2 S Upregulation, Nrf2 Activation and Antioxidant Proteins Levels in Renal Tubular Epithelial Cells Subjected to Anoxia and Reoxygenation [ Biomed Rep, 2020, 13(2):3]	PubMed: 32509306
Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells proliferation and survival under glucose deprivation [ Research Square, 2020, 10.21203/rs.3.rs-105979/v1]	PubMed: None

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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