Androgen Receptor Rabbit Recombinant mAb Datasheet

生物描述

特异性	Androgen Receptor (AR-V7 specific) Rabbit Recombinant mAb detects endogenous level of total Androgen Receptor (AR-V7 specific).
背景	androgen receptor (AR) plays a key role in development of male secondary sexual characteristics, and in the development and growth of the prostate. Abnormalities of the AR gene or protein are associated with a wide range of clinical conditions, including androgen-insensitivity syndrome (AIS), prostate cancer, and spinal and bulbar muscular atrophy (Kennedy disease). The nuclear import of the androgen receptor is crucial for its function. AR may also mediate important cellular functions in the cytoplasm, independent of its role as a transcription factor. For example, the AR has been shown to participate in rapid signaling cascades, primarily through direct association with the c-Src tyrosine kinase.

特异性

Androgen Receptor (AR-V7 specific) Rabbit Recombinant mAb detects endogenous level of total Androgen Receptor (AR-V7 specific).

背景

androgen receptor (AR) plays a key role in development of male secondary sexual characteristics, and in the development and growth of the prostate. Abnormalities of the AR gene or protein are associated with a wide range of clinical conditions, including androgen-insensitivity syndrome (AIS), prostate cancer, and spinal and bulbar muscular atrophy (Kennedy disease). The nuclear import of the androgen receptor is crucial for its function. AR may also mediate important cellular functions in the cytoplasm, independent of its role as a transcription factor. For example, the AR has been shown to participate in rapid signaling cascades, primarily through direct association with the c-Src tyrosine kinase.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human

MW (kDa)

80kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck