ASH2L Rabbit Recombinant mAb Datasheet

生物描述

特异性	ASH2L Rabbit Recombinant mAb detects endogenous level of total ASH2L.
背景	ASH2L is a component of MLL complexes conferring H3K4 trimethylation. In addition to the MLL complex, ASH2L is also present in another complex, which consists of ASH2L, RBBP5, and WDR5 without SET/MLL proteins which is also carries methyltransferase activity. ASH2L possesses histone methyltransferase activity when it forms a complex with a 26-amino acid short peptide from RBBP5 and can also bind DNA directly using a forkhead-like helix-wing-helix domain located on its N-terminal region. It has been shown to promote the transformation of primary fibroblast cells. ASH2L interacts with TBX1, AP2G, and MEF2 and is involved in their transcriptional activation.

特异性

ASH2L Rabbit Recombinant mAb detects endogenous level of total ASH2L.

背景

ASH2L is a component of MLL complexes conferring H3K4 trimethylation. In addition to the MLL complex, ASH2L is also present in another complex, which consists of ASH2L, RBBP5, and WDR5 without SET/MLL proteins which is also carries methyltransferase activity. ASH2L possesses histone methyltransferase activity when it forms a complex with a 26-amino acid short peptide from RBBP5 and can also bind DNA directly using a forkhead-like helix-wing-helix domain located on its N-terminal region. It has been shown to promote the transformation of primary fibroblast cells. ASH2L interacts with TBX1, AP2G, and MEF2 and is involved in their transcriptional activation.

使用信息

抗体应用

WB, IHC, IF,ELISA,ELISA

稀释比例

WB	IHC	IF
1:1000	1:50	1:50

反应性

Human Mouse Rat

MW (kDa)

69kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck

IF

Validated by Selleck