ATP citrate lyase Rabbit Recombinant mAb Datasheet

生物描述

特异性	ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
背景	ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. ACLY is a cross-link between glucose and/or glutamine metabolism and fatty acid synthesis and/or mevalonate pathways. Acetyl CoA is an essential substrate for fatty acid synthesis and mevalonate pathways. ACLY is upregulated in several types of cancer cells and that, upon inhibition of ACLY, cancer cells undergo a proliferation arrest both in vivo and in vitro. ACLY plays an important role in regulating histone acetylation levels in diverse mammalian cell types. It is required for optimal proliferation, and simply increasing nuclear-cytosolic acetyl-CoA production is insufficient to fully replace ACLY.

特异性

ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.

背景

ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. ACLY is a cross-link between glucose and/or glutamine metabolism and fatty acid synthesis and/or mevalonate pathways. Acetyl CoA is an essential substrate for fatty acid synthesis and mevalonate pathways. ACLY is upregulated in several types of cancer cells and that, upon inhibition of ACLY, cancer cells undergo a proliferation arrest both in vivo and in vitro. ACLY plays an important role in regulating histone acetylation levels in diverse mammalian cell types. It is required for optimal proliferation, and simply increasing nuclear-cytosolic acetyl-CoA production is insufficient to fully replace ACLY.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

122kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck