BRG1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	BRG1 Rabbit Recombinant mAb detects endogenous level of total BRG1.
背景	Brahma-related gene-1 (BRG1) is an ATPase and a core component of the SWI/SNF complex, which utilizes energy from ATP hydrolysis to disrupt or reposition nucleosomes and modify chromatin structure, thereby facilitating or inhibiting transcription of target genes or gene regions. In cells, BRG1 is found within the context of various multi-protein complexes, usually as the central enzymatic subunit, with roles in transcriptional regulation, DNA replication, repair and recombination. Among the various BRG1-containing complexes, the SWI/SNF family has been best characterized regarding structure, function and enzymatic activity. The BRG1 protein can also be found assembled with transcription factor and histone-modifying enzyme complexes to activate or repress nuclear processes including transcription, elongation and DNA replication. BRG1 is a bona fide tumor suppressor.

特异性

BRG1 Rabbit Recombinant mAb detects endogenous level of total BRG1.

背景

Brahma-related gene-1 (BRG1) is an ATPase and a core component of the SWI/SNF complex, which utilizes energy from ATP hydrolysis to disrupt or reposition nucleosomes and modify chromatin structure, thereby facilitating or inhibiting transcription of target genes or gene regions. In cells, BRG1 is found within the context of various multi-protein complexes, usually as the central enzymatic subunit, with roles in transcriptional regulation, DNA replication, repair and recombination. Among the various BRG1-containing complexes, the SWI/SNF family has been best characterized regarding structure, function and enzymatic activity. The BRG1 protein can also be found assembled with transcription factor and histone-modifying enzyme complexes to activate or repress nuclear processes including transcription, elongation and DNA replication. BRG1 is a bona fide tumor suppressor.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

185kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Shu Wu, et al. Annu Rev Immunol. 1998, 16:27-55.

Application Data

WB

Validated by Selleck