CCR7 Rabbit Recombinant mAb

生物描述

特异性

CCR7 Rabbit Recombinant mAb detects endogenous levels of total CCR7.

背景

The chemokine receptor CCR7 is mainly involved in lymphocyte and dendritic cell trafficking into and within lymphoid tissues. by guiding cells to and within lymphoid organs, CCR7 essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymphnode homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation induced lymphnode-bound migration of dendritic cells via afferent lymphatics. CCR7 is expressed by various subsets of immune cells and is also expressed by different non-immune cells, most notably in various malignancies. CCL19 and CCL21 are the only ligands for CCR7. CCR7 contains seven transmembrane-spanning domains and mediates its signals through heterotrimeric G proteins and their downstream effectors.

使用信息

抗体应用	IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:2000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	43kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Förster R, et al. Nat Rev Immunol. 2008, 8(5):362-71. [2] Sancho M, et al. J Endocrinol. 2006, 191(1):229-38.

Application Data

WB

IHC

IF