CD59 Rabbit Recombinant mAb

生物描述

特异性

CD59 Rabbit Recombinant mAb detects endogenous level of total CD59.

背景

CD59 is a glycosylphosphatidylinositol-anchored protein with regulatory properties on the activating cascades of the complement system. This regulation occurs through prevention of the terminal polymerization of the membrane attack complex by CD59. CD59 protein is the only membrane regulator that interferes directly on the MAC structure through its physical incorporation to the forming complex, avoiding the binding of C9 units to the C5b-8 complex. CD59 is a small globular glycoprotein, also anchored by GPI, of almost 20 kDa, belonging to the family of leukocytary antigen 6 (Ly-6). Due to its crucial role in preventing damages to the organism itself through inadequate deposition of MAC lithium complex, this protein is widely expressed in most tissues and in all circulating cells.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human
MW (kDa)	16kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ana Paula Alegretti, et al. Rev Bras Reumatol. 2009, 49(3).

Application Data

WB

IF