CDC42EP1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	CDC42EP1 Rabbit Recombinant mAb detects endogenous level of total CDC42EP1.
背景	The Rho GTPase family member Cdc42 regulates a diverse range of cellular functions including cytokinesis, cytoskeletal remodelling and cell polarity. Like other Rho family members, Cdc42 cycles between two tightly regulated conformational states, a GTP-bound active state and a GDP-bound inactive state. Activated Cdc42 exerts its functions by interacting with downstream effectors containing a Cdc42/Rac interactive binding (CRIB) motif. Several Cdc42 effector proteins, including kinases and scaffolds, have been well characterised. Cdc42 effector protein 1 (CDC42EP1) has been shown to interact with atypical PKC in mouse differentiating trophectoderm cells leading to increase cell motility, playing a role in regulating the migration and sorting of trophectoderm cells during embryogenesis.

特异性

CDC42EP1 Rabbit Recombinant mAb detects endogenous level of total CDC42EP1.

背景

The Rho GTPase family member Cdc42 regulates a diverse range of cellular functions including cytokinesis, cytoskeletal remodelling and cell polarity. Like other Rho family members, Cdc42 cycles between two tightly regulated conformational states, a GTP-bound active state and a GDP-bound inactive state. Activated Cdc42 exerts its functions by interacting with downstream effectors containing a Cdc42/Rac interactive binding (CRIB) motif. Several Cdc42 effector proteins, including kinases and scaffolds, have been well characterised. Cdc42 effector protein 1 (CDC42EP1) has been shown to interact with atypical PKC in mouse differentiating trophectoderm cells leading to increase cell motility, playing a role in regulating the migration and sorting of trophectoderm cells during embryogenesis.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

60kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Farrugia AJ, et al. Biochem Soc Trans. 2016, 44(6):1709-1716.

Application Data

WB

Validated by Selleck