Chk2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	Chk2 Rabbit Recombinant mAb detects endogenous level of total Chk2.
背景	Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Chk2 kinase activity is increased following DNA damage induced by ionizing radiation, chemotherapeutic agents, or other compounds that harm DNA directly or indirectly. Chk2 kinase activity is increased following DNA damage induced by ionizing radiation, chemotherapeutic agents, or other compounds that harm DNA directly or indirectly. Upon activation Chk2 relays the checkpoint activation signal to a number of effectors, which mediate many of the phenotypic characteristics provoked by DNA damage including cell cycle arrest and apoptosis.

特异性

Chk2 Rabbit Recombinant mAb detects endogenous level of total Chk2.

背景

Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Chk2 kinase activity is increased following DNA damage induced by ionizing radiation, chemotherapeutic agents, or other compounds that harm DNA directly or indirectly. Chk2 kinase activity is increased following DNA damage induced by ionizing radiation, chemotherapeutic agents, or other compounds that harm DNA directly or indirectly. Upon activation Chk2 relays the checkpoint activation signal to a number of effectors, which mediate many of the phenotypic characteristics provoked by DNA damage including cell cycle arrest and apoptosis.

使用信息

抗体应用

WB, IHC, IF,ELISA,ELISA

稀释比例

WB	IHC	IF
1:1000	1:50	1:50

反应性

Human

MW (kDa)

62kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Ahn J, et al. DNA Repair (Amst). 2004, 3(8-9):1039-47.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck

IF

Validated by Selleck