COX1 Rabbit Recombinant mAb

目录号：A5555

打印

生物描述

特异性 COX1 Rabbit Recombinant mAb detects endogenous level of total COX1.
背景 The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). Prostaglandins play critical roles in numerous biologic processes, including the regulation of immune function, kidney development, reproductive biology, and gastrointestinal integrity. COX exists in 2 isoforms, referred to as COX-1 and COX-2. COX-1 is constitutively expressed at high levels maintaining normal housekeeping functions while COX-2 is expressed at low levels in the kidney under normal physiological conditions and is highly induced in response to inflammation and renal injury which results in enhanced synthesis of PGs in neoplastic and inflamed tissues. COX-1 and COX-2 are located in the endoplasmic reticulum and nuclear envelope but that COX-2 is more highly concentrated in the nuclear envelope.

使用信息

抗体应用 WB, IHC,ELISA,ELISA
稀释比例
WB IHC
1:1000 1:50
反应性 Human Mouse Rat
MW (kDa) 70kDa
抗体类型 Rabbit
储存液配方 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件
(自收到货起)		 Store at –20°C.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck