Cyclothiazide

目录号：S6611 批次号：S661101

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₄H₁₆ClN₃O₄S₂
	分子量	389.88	CAS号	2259-96-3
Solubility (25°C)*	体外	DMSO	78 mg/mL (200.06 mM)
		Ethanol	19 mg/mL (48.73 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Cyclothiazide是AMPA-type glutamate receptors（AMPA型谷氨酸受体）正向别构调节剂，在神经发育与功能中发挥关键作用。

靶点

AMPA-type receptors ^[1]

参考文献

[1] Sergio Fucile, et al. Proc Natl Acad Sci U S A. 2006, 103(8): 2943–2947.

Cyclothiazide在文献中得到引用

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GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A [ iScience, 2022, 25-9:104952]	PubMed: 36065190
SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth [ Adv Sci (Weinh), 2021, e2004846]	PubMed: 34060252
SPOPandOTUD7AControlEWS–FLI1Protein Stability to Govern Ewing Sarcoma Growth [ ADVANCED SCIENCE, 2021, 8(14)]	PubMed: None
Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells [ Cell Death Discov, 2021, 7(1):201]	PubMed: 34349107
TRIM16 overexpression inhibits the metastasis of colorectal cancer through mediating Snail degradation [ Exp Cell Res, 2021, 406(1):112735]	PubMed: 34265287
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. [ Cell Death Differ, 2020, 27(3):1105-1118]	PubMed: 31406303
Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells Through Destabilizing AKT [ Int J Biol Sci, 2020, 25;16(11):1774-1784]	PubMed: 32398948
Design and synthesis of selective degraders of EGFRL858R/T790M mutant. [ Eur J Med Chem, 2020, 15;192:112199]	PubMed: 32171162
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. [ Cell Death Dis, 2018, 9(5):556]	PubMed: 29748581

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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