Cytochrome P450 2D6 Rabbit Recombinant mAb Datasheet

生物描述

特异性	Cytochrome P450 2D6 Rabbit Recombinant mAb detects endogenous level of total Cytochrome P450 2D6.
背景	The cytochrome P450 2D6 (CYP2D6) is part of the cytochrome P450 gene family--a group of enzymes that is responsible for phase I metabolism and elimination of numerous endogenous substrates and a diverse array of drugs. Among the drug-metabolizing cytochrome P450s, CYP2D6 is the only noninducible enzyme, which results in a large contribution of genetic variation to the interindividual variation in enzyme activity. CYP2D6 is highly polymorphic, with over 90 known allelic variants. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

特异性

Cytochrome P450 2D6 Rabbit Recombinant mAb detects endogenous level of total Cytochrome P450 2D6.

背景

The cytochrome P450 2D6 (CYP2D6) is part of the cytochrome P450 gene family--a group of enzymes that is responsible for phase I metabolism and elimination of numerous endogenous substrates and a diverse array of drugs. Among the drug-metabolizing cytochrome P450s, CYP2D6 is the only noninducible enzyme, which results in a large contribution of genetic variation to the interindividual variation in enzyme activity. CYP2D6 is highly polymorphic, with over 90 known allelic variants. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human

MW (kDa)

50,55,80kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Ryan P. Owen, et al. Pharmacogenet Genomics. 2009, 19(7): 559–562.

Application Data

WB

Validated by Selleck

IF

Validated by Selleck