DDIT3 Rabbit Recombinant mAb Datasheet

生物描述

特异性	DDIT3 Rabbit Recombinant mAb detects endogenous level of total DDIT3.
背景	DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress response. DNA damage, ER stress, hypoxia, and starvation induce DDIT3 transcription, mRNA stability, and translation, resulting in DDIT3 protein accumulation. The biological activity of the DDIT3 protein is further regulated by phosphorylation. Forced expression of DDIT3 triggers cell cycle arrest and in some cell types apoptosis. DDIT3 has been implicated in stress responses leading to death of pancreatic insulin producing β-cells and in neurodegenerative disorders. DDIT3 is also involved in differentiation of specialized tissues and cells and as an oncogene in sarcomas.

特异性

DDIT3 Rabbit Recombinant mAb detects endogenous level of total DDIT3.

背景

DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress response. DNA damage, ER stress, hypoxia, and starvation induce DDIT3 transcription, mRNA stability, and translation, resulting in DDIT3 protein accumulation. The biological activity of the DDIT3 protein is further regulated by phosphorylation. Forced expression of DDIT3 triggers cell cycle arrest and in some cell types apoptosis. DDIT3 has been implicated in stress responses leading to death of pancreatic insulin producing β-cells and in neurodegenerative disorders. DDIT3 is also involved in differentiation of specialized tissues and cells and as an oncogene in sarcomas.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

27kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Jauhiainen A, et al. PLoS One. 2012, 7(4):e33208.

Application Data

WB

Validated by Selleck