Digoxin

目录号：S4290 批次号：S429005

化学数据

	别名	NSC 95100, 12β-Hydroxydigitoxin	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₄₁H₆₄O₁₄
	分子量	780.94	CAS号	20830-75-5
Solubility (25°C)*	体外	DMSO	85 mg/mL (108.84 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Digoxin是一种经典的Na,K-ATPase抑制剂，其对α2β3亚型的选择性高于α1β1亚型，用于治疗心房颤动和心脏衰竭。此产品为危化品（急性毒性/易燃/皮肤腐蚀），请在穿戴防护面罩、防护手套和防护服后使用。

靶点

Na,K-ATPase α2β3 ^[1]	Na,K-ATPase α2β1 ^[1]	Na,K-ATPase α1β1 ^[1]
42.8 nM(Ki)	58.7 nM(Ki)	268 nM(Ki)

参考文献

[1] Katz A, et al. Proc Natl Acad Sci U S A. 2015, 112(44):13723-8.

Digoxin在文献中得到引用

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3]	PubMed: 38262581
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction [ Autophagy, 2023, 19(6):1803-1820]	PubMed: 36588318
IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer [ EMBO J, 2023, e110620.]	PubMed: 36637036
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer [ Cancer Res, 2023, 83(1):141-157]	PubMed: 36346366
Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping [ Int J Mol Sci, 2022, 23(21)12948]	PubMed: 36361734
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure [ Biomolecules, 2021, 11(9)1370]	PubMed: 34572583
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization [ J Cell Mol Med, 2021, 10.1111/jcmm.16272]	PubMed: 33438362
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization [ J Cell Mol Med, 2021, 25(3):1700-1711]	PubMed: 33438362
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. [ PLoS Pathog, 2020, 16;16(3):e1008341]	PubMed: 32176725
The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis [ J Lipid Res, 2020, 61(12):1617-1628]	PubMed: 32848049

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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