Dynamin 2 Rabbit Recombinant mAb

生物描述

特异性

Dynamin 2 Rabbit Recombinant mAb detects endogenous level of total Dynamin 2.

背景

Dynamin is the founding member of a family of GTPases that have diverse roles in membrane-remodelling events throughout the cell. Mammalian genomes contain three dynamin genes: they have distinct expression patterns. Dynamin 1 is selectively expressed at high levels in neurons and is generally not present in non-neuronal tissues. Dynamin 2 is expressed ubiquitously. Dynamin 3 is found predominantly in the brain (at much lower levels than dynamin 1) and testis, and at lower levels in some tissues, such as the lung. Dynamin 2 concentrates at sites of abscission and was implicated in the completion of cytokinesis. Dynamin 2 is phosphorylated during mitosis by cyclin-dependent kinase 1 (CDK1), and its dephosphorylation by calcineurin at these sites is required during cytokinesis. Dynamin 2 also mediates the internalization and infectivity of bacterial and viral pathogens, including HIV.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	98kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Shawn M. Ferguson & Pietro De Camilli. Nature Reviews Molecular Cell Biology. 2012, 13:75-88.

Application Data

WB

IHC

IF