Molnupiravir (EIDD-2801)

目录号：S8969 批次号：S896902

化学数据

	别名	MK-4482	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₃H₁₉N₃O₇
	分子量	329.31	CAS号	2349386-89-4
Solubility (25°C)*	体外	DMSO	66 mg/mL (200.41 mM)
		Ethanol	33 mg/mL (100.2 mM)
		Water	17 mg/mL (51.62 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Molnupiravir (EIDD-2801, MK-4482) 是一种口服生物活性的核糖核苷类似物β-d-N⁴-hydroxycytidine (NHC; EIDD-1931)的前药，具有广谱的抗病毒活性 antiviral activity 对抗 SARS-CoV-2、MERS-CoV、SARS-CoV 和 COVID-19的病原体。

靶点

SARS-CoV-2 ^[1]

MERS-CoV ^[1]

SARS-CoV ^[1]

参考文献

Molnupiravir (EIDD-2801)在文献中得到引用

The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance [ Antiviral Res, 2024, 225:105840]	PubMed: 38438015
A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry [ Cell, 2023, 186(4):850-863.e16]	PubMed: 36803605
Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation [ Nat Commun, 2023, 14(1):199]	PubMed: 36639383
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells [ Elife, 2022, 11e74443]	PubMed: 35666101
Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor [ Antiviral Res, 2022, 203:105343]	PubMed: 35598779
In vitro and in vivo efficacy of a novel nucleoside analog H44 against Crimean-Congo hemorrhagic fever virus [ Antiviral Res, 2022, 199:105273]	PubMed: 35257725
The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs [ Pharmaceutics, 2022, 14(9)1776]	PubMed: 36145524
Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection [ Viruses, 2022, 14(11)2417]	PubMed: 36366514
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients [ J Cell Biochem, 2022, 10.1002/jcb.30213]	PubMed: 35037717

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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