ERR alpha Rabbit Recombinant mAb Datasheet

生物描述

特异性	ERR alpha Rabbit Recombinant mAb detects endogenous levels of total ERR.
背景	Estrogen-Related Receptors (ERRs) are classified as orphan nuclear receptors that determine metabolic phenotype through their role as transcription factors. Three ERR isoforms (α, β and γ) regulate a large array of target genes involved in glycolysis, β-oxidation of fatty acids, TCA cycle, oxidative phosphorylation and mitochondrial biogenesis. The ERRα isoform is highly expressed in tissues that require large amounts of energy and can be induced in response to stimuli that further increase energy demand such as cold-induced browning of adipose tissue, exercised skeletal muscle, and liver and kidney tissue of fasting animals. ERRα functions downstream of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha and beta (PGC-1α and PGC-1β) and regulates the expression of genes involved in energy metabolism and mitochondrial biogenesis such as genes encoding enzymes and proteins of the tricarboxylic acid cycle, pyruvate metabolism, oxidative phosphorylation, and electron transport.

特异性

ERR alpha Rabbit Recombinant mAb detects endogenous levels of total ERR.

背景

Estrogen-Related Receptors (ERRs) are classified as orphan nuclear receptors that determine metabolic phenotype through their role as transcription factors. Three ERR isoforms (α, β and γ) regulate a large array of target genes involved in glycolysis, β-oxidation of fatty acids, TCA cycle, oxidative phosphorylation and mitochondrial biogenesis. The ERRα isoform is highly expressed in tissues that require large amounts of energy and can be induced in response to stimuli that further increase energy demand such as cold-induced browning of adipose tissue, exercised skeletal muscle, and liver and kidney tissue of fasting animals. ERRα functions downstream of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha and beta (PGC-1α and PGC-1β) and regulates the expression of genes involved in energy metabolism and mitochondrial biogenesis such as genes encoding enzymes and proteins of the tricarboxylic acid cycle, pyruvate metabolism, oxidative phosphorylation, and electron transport.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

50kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck

IF

Validated by Selleck