FMRP Rabbit Recombinant mAb

生物描述

特异性

FMRP Rabbit Recombinant mAb detects endogenous level of total FMRP.

背景

FMRP (Fragile X Mental Retardation Protein) is an RNA binding protein that is part of a ribonucleoprotein particle associated to actively translating polyribosomes, and which can shuttle between nucleus and cytoplasm. FMRP is ubiquitously expressed with higher abundance in the brain and testis. FMRP is known to play roles in nucleocytoplasmic shuttling of mRNA by a non-canonical nuclear localization signal (NLS) and a nuclear export signal (NES). Several FMRP interacting proteins have been identified so far. FXR1P and FXR2P are structurally and functionally related to FMRP. They additionally harbor a functional nucleolar targeting signal. The cytoplasmic interacting FMR1 protein (CYFIP; also known as p140 and PIR121, respectively), a binding partner of FMRP, acts as a downstream effector of Rac1 thereby linking Rac1 to actin dynamics and lamellipodia formation. Activated Rac1 binds CYFIP and sequesters it from its complex with FMRP, which in turn is then released to regulate protein translation. FMRP localizes predominantly in different cellular compartments, including mitochondria and nucleoli.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	71kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Tabet R, et al. Proc Natl Acad Sci U S A. 2016, 113(26):E3619-28. [2] Taha MS, et al. PLoS One. 2014, 9(3):e91465.

Application Data

WB

IHC