生物描述

特异性

GC1q R Rabbit Recombinant mAb detects endogenous levels of total GC1q R.

背景

The gC1qR (i.e., gC1q receptor, gC1q binding protein, p32, p33) is a multifunctional cellular protein that interacts with components of the complement, kinin, and coagulation cascades and select microbial pathogens. Enhanced gC1qR expression occurs not only in dysplasia and malignancy but also in normal biological processes that are associated with cell proliferation and, in some cases, cell activation. In contrast, gC1qR expression in malignant and benign conditions involving cells of mesenchymal derivation was, overall, considerably weaker when compared to tissues of epithelial derivation, in which malignant tissue, without exception, expressed gC1qR strongly. Thus, gC1qR expression may be a phenotypic marker of epithelial tumors and could be informative in tumors undergoing epithelial to mesenchymal or mesenchymal to epithelial transitions. gC1qR is a ubiquitously expressed, distributed both intracellularly and on the cell-surface. Enhanced expression of gC1qR would in turn lead to: (i) high-affinity C1q binding and cell production of proinflammatory factors, and (ii) high-affinity high-molecular-weight kininogen (HK) binding and facilitation of the assembly of contact activation proteins leading to generation of bradykinin and possibly coagulation through activation of factor XI (FXI).

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	31kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Francine R. Dembitzer, et al. J Histochem Cytochem. 2012, 60(6): 467–474. [2] Ghebrehiwet B, et al. Adv Exp Med Biol. 2006, 586:95-105.

Application Data

WB

IF