Datasheet

生物描述

特异性	GCSF Receptor (CD114) Rabbit Recombinant mAb detects endogenous levels of total GCSF Receptor (CD114).
背景	CD114 is a cell surface marker and also a marker for CSCs in neural crest-derived tumors. CD114 also expresses in the pathogenesis of various tumor types, including melanoma,ovarian carcinoma, bladder cancer, and skin cancers. CD114 ligand-binding is associated with dimerization of the receptor and signal transduction through multiple intracellular pathways, including the JAK/STAT and RAS/MAPK pathways. CD114 is present on the surfaces of precursor cells in the bone marrow, and, in response to stimulation by GCSF, initiates cell proliferation and differentiation of myeloid precursors into mature granulocytes and macrophages. CD114 is also expressed on the surfaces of neuronal and neural crest-derived cell types, and signaling via CD114 promotes neurogenesis and the survival and expansion of neural stem cells and regeneration of neural tissue after stroke.

特异性

GCSF Receptor (CD114) Rabbit Recombinant mAb detects endogenous levels of total GCSF Receptor (CD114).

背景

CD114 is a cell surface marker and also a marker for CSCs in neural crest-derived tumors. CD114 also expresses in the pathogenesis of various tumor types, including melanoma,ovarian carcinoma, bladder cancer, and skin cancers. CD114 ligand-binding is associated with dimerization of the receptor and signal transduction through multiple intracellular pathways, including the JAK/STAT and RAS/MAPK pathways. CD114 is present on the surfaces of precursor cells in the bone marrow, and, in response to stimulation by GCSF, initiates cell proliferation and differentiation of myeloid precursors into mature granulocytes and macrophages. CD114 is also expressed on the surfaces of neuronal and neural crest-derived cell types, and signaling via CD114 promotes neurogenesis and the survival and expansion of neural stem cells and regeneration of neural tissue after stroke.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

92kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Zage PE, et al. J Cell Biochem. 2017, 118(2):221-231.

Application Data

WB

Validated by Selleck