Gefitinib hydrochloride

目录号：S5098 批次号：S509803

化学数据

	别名	ZD1839 hydrochloride	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₂H₂₄ClFN₄O₃.HCl
	分子量	483.36	CAS号	184475-55-6
Solubility (25°C)*	体外	Water	10 mg/mL (20.68 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.

靶点

EGFR ^[1] (Cell-free assay)	EGFR (858R/T790M) ^[1] (Cell-free assay)
15.5 nM	823.3 nM

参考文献

[1] Li Y, et al. Molecules. 2016, 21(11), pii: E1462.

Gefitinib hydrochloride在文献中得到引用

Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition [ Cancer Res, 2023, 83(2):316-331]	PubMed: 36409827
Irreversible tyrosine kinase inhibitors induce the endocytosis and downregulation of ErbB2 [ Biochem Biophys Rep, 2023, 34:101436]	PubMed: 36824069
Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma [ Mol Cancer, 2022, 21(1):43]	PubMed: 35144642
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select [ Nat Genet, 2022, 54(12):1983-1993]	PubMed: 36471068
Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity [ Adv Sci (Weinh), 2022, e2201539]	PubMed: 35652270
The reversible fourth-generation EGFR tyrosine kinase inhibitor OBX02-011 overcomes C797S-mediated resistance in lung cancer [ Cancer Res, 2022, canres.0394.2022-2-3 21:03:12.200]	PubMed: 35700239
Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR [ Cell Death Dis, 2022, 13(1):41]	PubMed: 35013118
Multi-omics analysis reveals the mechanisms of action and therapeutic regimens of traditional Chinese medicine, Bufei Jianpi granules: Implication for COPD drug discovery [ Phytomedicine, 2022, 98:153963]	PubMed: 35121390
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies [ Antiviral Res, 2022, 204:105367]	PubMed: 35738348
Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer [ J Med Chem, 2022, 65(14):9662-9677]	PubMed: 35838760

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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