GSH (Glutathione)

目录号：S4606 批次号：S460603

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化学数据

化学结构式 别名 Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine 储存条件
(自收到货起)		 3年 -20°C(避光) 粉状
化学式

C10H17N3O6S
分子量 307.32 CAS号 70-18-8
Solubility (25°C)* 体外 Water 46 mg/mL (149.68 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 GSH (Glutathione)是一种抗氧化剂，自由基清除剂以及解毒剂。它是由三种氨基酸（半胱氨酸、谷氨酸和甘氨酸）组成的三肽，出现在大多数哺乳动物组织内。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

GSH (Glutathione)在文献中得到引用

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758] PubMed: 37553341
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758] PubMed: 37553341
Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity [ J Exp Clin Cancer Res, 2023, 42(1):118] PubMed: 37161450
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria [ Cell Rep, 2023, 42(9):113147] PubMed: 37756158
Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis [ Cancer Cell Int, 2023, 23(1):5] PubMed: 36639654
Glutathione promotes the synergistic effects of venetoclax and azacytidine against myelodysplastic syndrome‑refractory anemia by regulating the cell cycle [ Exp Ther Med, 2023, 26(6):574] PubMed: 38023359
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis [ Cell Stem Cell, 2022, 29(7):1119-1134.e7] PubMed: 35803229
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models [ Nat Commun, 2022, 13(1):7335] PubMed: 36443325
Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response [ Environ Int, 2022, 158:106989] PubMed: 34991250
HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis [ Cell Death Dis, 2022, 13(10):861] PubMed: 36209275

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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