GSK3 beta Rabbit Recombinant mAb

生物描述

特异性

GSK3 beta Rabbit Recombinant mAb detects endogenous levels of total GSK3 beta.

背景

GSK3B (Glycogen Synthase Kinase 3 Beta) is one of isoforms of GSK3 which is a serine-threonine kinase. GSK3 was originally discovered as an important enzyme in glycogen metabolism and now it was also shown to function in cellular division, proliferation, motility and survival. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Diseases associated with GSK3B include Alzheimer Disease and Bipolar Disorder.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse
MW (kDa)	46kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Cohen P, et al. Nat Rev Mol Cell Biol. 2001, 2(10):769-76. [2] Beurel E, et al. Pharmacol Ther. 2015, 148:114-31. [3] Metcalfe C, et al. J Cell Sci. 2011, 124(Pt 21):3537-44.

Application Data

WB

IHC

IF