HMGB2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	HMGB2 Rabbit Recombinant mAb detects endogenous level of HMGB2.
背景	The high-mobility group (HMG) superfamily consists of three families, HMGA, HMGB and HMGN, all of which are chromatin- binding proteins that share similarities in structural and functional properties. It has been well documented that HMG proteins not only act as dynamic modulators of chromatin architecture but also especially influence DNA replication, recombination, repair and transcriptional regulation. There are three members of HMGB proteins in mammals, HMGB1, HMGB2 and HMGB3. They are involved in multiple biochemical and molecular activities, such as the innate immunity response, necrosis, arthritis and tumorigenesis. It has been demonstrated that as a transcriptional co-regulator. HMGB2 regulates various differentiation programs, including erythropoiesis, chondrogenesis and spermatogenesis. HMGB2 is required for cell cycle progression and is mainly expressed in developing embryo and stem cells, including mesenchymal stem cells, embryonic stem cells and spermatocytes.

特异性

HMGB2 Rabbit Recombinant mAb detects endogenous level of HMGB2.

背景

The high-mobility group (HMG) superfamily consists of three families, HMGA, HMGB and HMGN, all of which are chromatin- binding proteins that share similarities in structural and functional properties. It has been well documented that HMG proteins not only act as dynamic modulators of chromatin architecture but also especially influence DNA replication, recombination, repair and transcriptional regulation. There are three members of HMGB proteins in mammals, HMGB1, HMGB2 and HMGB3. They are involved in multiple biochemical and molecular activities, such as the innate immunity response, necrosis, arthritis and tumorigenesis. It has been demonstrated that as a transcriptional co-regulator. HMGB2 regulates various differentiation programs, including erythropoiesis, chondrogenesis and spermatogenesis. HMGB2 is required for cell cycle progression and is mainly expressed in developing embryo and stem cells, including mesenchymal stem cells, embryonic stem cells and spermatocytes.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

24kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck