Hsc70 Rabbit Recombinant mAb Datasheet

生物描述

特异性	Hsc70 Rabbit Recombinant mAb detects endogenous levels of total Hsc70.
背景	Hsc70, also known as Hsp73 or HSPA8 is a heat shock protein and a chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. Hsc70 represents constitutively expressed, cognate protein of the HSP70 family. It is the main housekeeping protein of the family and acts as a clathrin-uncoating ATPase during clathrin-mediated endocytosis. HSPA8 also displays important functions in cellular protein degradation, protein folding and protein import into organelles or cellular compartments. The chaperone is able to shuttle between the nucleus and the cytoplasm in an ATP-dependent manner. This property enables HSPA8 to import different cytoplasmic proteins into the nucleus such as karyophilic proteins. Besides its ntracellular location. HSPA8 is also detected in the extracellular space. Extracellular HSPA8 inhibits tumor cell growth and modifies cell viability. HSPA8 also associates with the cell surface where it might contribute to cell recognition by immune cellor act as a cellular receptor for viral infe.

特异性

Hsc70 Rabbit Recombinant mAb detects endogenous levels of total Hsc70.

背景

Hsc70, also known as Hsp73 or HSPA8 is a heat shock protein and a chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. Hsc70 represents constitutively expressed, cognate protein of the HSP70 family. It is the main housekeeping protein of the family and acts as a clathrin-uncoating ATPase during clathrin-mediated endocytosis. HSPA8 also displays important functions in cellular protein degradation, protein folding and protein import into organelles or cellular compartments. The chaperone is able to shuttle between the nucleus and the cytoplasm in an ATP-dependent manner. This property enables HSPA8 to import different cytoplasmic proteins into the nucleus such as karyophilic proteins. Besides its ntracellular location. HSPA8 is also detected in the extracellular space. Extracellular HSPA8 inhibits tumor cell growth and modifies cell viability. HSPA8 also associates with the cell surface where it might contribute to cell recognition by immune cellor act as a cellular receptor for viral infe.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

70kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck

IF

Validated by Selleck