Hsp70 Rabbit Recombinant mAb

Hsp70 Rabbit Recombinant mAb detects endogenous levels of total Hsp70.

Hsp70s are a family of conserved ubiquitously expressed heat shock proteins which are an important part of the cell's machinery for protein folding, and help to protect cells from stress. When not interacting with a substrate peptide, Hsp70 is usually in an ATP bound state. In the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis. When ATP is hydrolyzed to ADP the binding pocket of Hsp70 closes, tightly binding the now-trapped peptide chain.