全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
目录号:A5933
特异性 | Huntingtin Rabbit Recombinant mAb detects endogenous levels of total Huntingtin. |
---|---|
背景 | Huntington's Disease (HD) is a progressive and disabling neurodegenerative disorder of the central nervous system. This disease is caused by inheritance of an autosomal dominant mutation in the Huntingtin (Htt) protein. Huntingtin (Htt) is widely expressed during development and has a complex and dynamic distribution within cells. It is predicted to be a protein of pleiotropic function, interacting with a large number of effector proteins to mediate a host of physiological processes. A large number of Htt protein interactors function in microtubule-based axon trafficking. Huntingtin-associated protein 1 (HAP1) helps mediate the interaction between Htt, microtubule motor proteins and their co-factors, including kinesin, dynactin, and dynein. Huntingtin is involved in both antero- and retrograde axon transport. Htt associates with the endocytosis proteins clathrin and dynamin, as well as endocytic organelle trafficking proteins such as Endophilin 3, α-Adaptin, HIP-14, HAP1, and Huntingtin-associated protein 40 (HAP40). Htt is also associated with the movement of mitochondria along neurites and has neuroprotective functions during numerous proapoptotic challenges. |
抗体应用 | WB, IHC,ELISA,ELISA | ||||
---|---|---|---|---|---|
稀释比例 |
|
||||
反应性 | Human Mouse Rat | ||||
MW (kDa) | 348kDa | ||||
抗体类型 | |||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||
储存条件 (自收到货起) |
Store at –20°C. |
WB
Validated by Selleck
IHC
Validated by Selleck