Hydroxychloroquine (HCQ) Sulfate

目录号：S4430 批次号：S443010

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化学数据

化学结构式 别名 NSC 4375 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C18H28ClN3O5S
分子量 433.95 CAS号 747-36-4
Solubility (25°C)* 体外 Water 87 mg/mL (200.48 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Hydroxychloroquine (HCQ) Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。
靶点
TLR9 [5] Autophagy [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Clin Cancer Res, 2018, doi:10.1158/1078-0432.CCR-18-1489]

数据来源于[Data independently produced by , , J Exp Clin Cancer Res, 2018, 37(1):272]

数据来源于[Data independently produced by , , Cell Death Dis, 2017, 8(1):e2558]

数据来源于[Data independently produced by , , Oxid Med Cell Longev, 2017, 8519169]

Hydroxychloroquine (HCQ) Sulfate在文献中得到引用

Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex [ Phytomedicine, 2024, 10.1016/j.phymed.2023.155152] PubMed: 37922793
ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus [ PLoS Pathog, 2024, 20(1):e1011958] PubMed: 38227600
The nucleotide-sensing Toll-Like Receptor 9/Toll-Like Receptor 7 system is a potential therapeutic target for IgA nephropathy [ Kidney Int, 2023, 104(5):943-955] PubMed: 37648155
Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis [ Nat Commun, 2023, 14(1):822] PubMed: 36788228
AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer [ J Exp Clin Cancer Res, 2023, 42(1):204] PubMed: 37563661
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer [ Cancer Res, 2023, 83(1):141-157] PubMed: 36346366
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis [ Pharmacol Res, 2023, 197:106955] PubMed: 37820855
Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury [ JCI Insight, 2023, 8(22)e171054] PubMed: 37991024
PSGL-1 is an evolutionarily conserved antiviral restriction factor [ mBio, 2023, 10.1128/mbio.00387-23] PubMed: 37787515
Piperine Induces Apoptosis and Autophagy in HSC-3 Human Oral Cancer Cells by Regulating PI3K Signaling Pathway [ Int J Mol Sci, 2023, 24(18)13949] PubMed: 37762259

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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