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特异性 | Integrin alpha V Rabbit Recombinant mAb detects endogenous level of total Integrin alpha V. |
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背景 | Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. They have been shown to play important roles in embryonic development, wound healing, metastasis, and other biological processes. Integrins are formed through noncovalent association of two type I transmembrane glycoproteins, the α- and the β subunit. αv integrins (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) mediate cell adhesion to various matrix proteins including fibronectin, vitronectin, tenascin, osteopontin, and fibrinogen at sites containing the tripeptide sequence arginine-glycine-aspartic acid (RGD). In addition to recognizing distinct subsets of RGD-containing ligands, αv integrins have been reported to exert distinct effects on cell behavior. αvβ5 is widely expressed on epithelial cells including keratinocytes, airway epithelial cells, fibroblasts, osteoclasts, and monocytes. αvβ5 has been suggested to play important roles in activation-dependent cell migration, in promoting adenovirus-mediated gene delivery, and in cutaneous wound healing. |
抗体应用 | WB, IHC, IF,ELISA,ELISA | ||||||
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稀释比例 |
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反应性 | Human Mouse Rat | ||||||
MW (kDa) | 26kDa/125kDa | ||||||
抗体类型 | Rabbit | ||||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck
IHC
Validated by Selleck
IF
Validated by Selleck