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特异性 | Interferon gamma Rabbit Recombinant mAb detects endogenous level of total Interferon gamma. |
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背景 | The IFN family of cytokines is divided into type I and type II IFNs. IFN-γ is at present the only type II interferon identified and activates a distinct type II receptor. IFN-γ has a multitude of functions, displaying direct antiviral activity as well as a variety of immunomodulatory and inflammatory roles. Specific actions of IFN-γ signaling include: stimulation of antigen presentation through induced expression of Class I and II major histocompatibility complex (MHC) molecules on the surface of macrophages and T-lymphocytes; antigen processing; control of Th1 and Th2 balance; activation of macrophages, T-lymphocytes and NK cells; stimulation of cytokine production in target cells; and recruitment of cells to the site of injury through increased expression of chemokines and adhesion molecules. IFN-γ also influences cellular state including regulation of the rate of proliferation, differentiation and apoptosis. Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation. It decreases cytokine-induced activation of STAT3 while increasing STAT1 signaling. IFN-γ induces internalization of the common cytokine receptor gp130 by activating p38 signaling. |
抗体应用 | WB ,ELISA,ELISA | ||
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稀释比例 |
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反应性 | Human Mouse Rat | ||
MW (kDa) | 25kDa | ||
抗体类型 | Rabbit | ||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck