JNK1/2/3 Rabbit Recombinant mAb

JNK1+JNK2+JNK3 Rabbit Recombinant mAb detects endogenous levels of total JNK1+JNK2+JNK3.

c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase family. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII and is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). JNK1 and JNK2 are found in all cells and tissues. JNK3 is found mainly in the brain, but is also found in the heart and the testes. They are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock and is involved in several biological processes such as inflammation, DNA repair, apoptosis cell differentiation and proliferation.