JNK3 Rabbit Recombinant mAb

生物描述

特异性

JNK3 Rabbit Recombinant mAb detects endogenous level of total JNK3.

背景

The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. JNK signaling is an important contributor to stress-induced apoptosis. Once activated, JNK phosphorylates serine-63 and -73 residues of c-Jun and increases the transcription activity of the AP-1 complex. JNK signaling also targets the mitochondria and regulates the release of cytochrome c. Among the three JNK isoforms (JNK1, JNK2, JNK3), JNK1 and JNK2 are present in most tissues, whereas JNK3 is selectively expressed in the nervous system and in the heart. JNK1 is the major isoform responsible for the high level of basal JNK activity in the brain and JNK3 is a critical component of the stress-induced JNK signaling and neuronal apoptosis.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:500 1:50
反应性	Human Mouse Rat
MW (kDa)	53kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Xie X, et al. Structure. 1998, 6(8):983-91. [2] Kuan CY, et al. Proc Natl Acad Sci U S A. 2003, 100(25):15184-9.

Application Data

WB

IF