KAP1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	KAP1 Rabbit Recombinant mAb detects endogenous level of total KAP1.
背景	KAP1 is a member of a family of ∼60 human TRIM genes and is highly related to three other TRIM proteins, TIF1α, TIF1γ, and TIF1δ. KAP1 is a critical regulator of normal development and differentiation. It is also involved in maintaining pluripotency, is required for terminal differentiation of mouse embryonic stem cells and has been associated with promoting and inhibiting differentiation of different adult cell types. KAP1 plays a critical role in proliferation and differentiation of both normal and tumor cells. KAP1 is a scaffold protein that can assemble epigenetic machinery. It interacts with histone methyltransferases and HDACs via a C-terminal PHD and bromodomain. Post-translational modifications regulate KAP1 function; sumoylated KAP1 is involved in transcriptional repression, whereas phosphorylated KAP1 is involved in DNA repair.

特异性

KAP1 Rabbit Recombinant mAb detects endogenous level of total KAP1.

背景

KAP1 is a member of a family of ∼60 human TRIM genes and is highly related to three other TRIM proteins, TIF1α, TIF1γ, and TIF1δ. KAP1 is a critical regulator of normal development and differentiation. It is also involved in maintaining pluripotency, is required for terminal differentiation of mouse embryonic stem cells and has been associated with promoting and inhibiting differentiation of different adult cell types. KAP1 plays a critical role in proliferation and differentiation of both normal and tumor cells. KAP1 is a scaffold protein that can assemble epigenetic machinery. It interacts with histone methyltransferases and HDACs via a C-terminal PHD and bromodomain. Post-translational modifications regulate KAP1 function; sumoylated KAP1 is involved in transcriptional repression, whereas phosphorylated KAP1 is involved in DNA repair.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

110kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Sushma Iyengar, et al. J Biol Chem. 2011, 286(30): 26267–26276.

Application Data

WB

Validated by Selleck