KIF3A Rabbit Recombinant mAb

生物描述

特异性

KIF3A Rabbit Recombinant mAb detects endogenous level of total KIF3A.

背景

Kinesin superfamily proteins (KIFs) comprise several dozen molecular motor proteins. The KIF3 heterotrimer complex is one of the most abundantly and ubiquitously expressed KIFs in mammalian cells. KIF3A is best known for its role in molecule transport along the axoneme of cilia, and loss of KIF3A causes defects in cilium biogenesis. Also, KIF3A forms a complex with APC and participates in the transport of APC, supporting cell migration and polarization. Additionally, KIF3A constrains the activity of the Wnt/β-catenin pathway by suppressing casein kinase 1 (CK1)-dependent DVL phosphorylation, which is a key step in Wnt signalling.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	80kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Kim M, et al. Sci Rep. 2016, 6:32770. [2] Takeda S, et al. J Cell Biol. 2000, 148(6):1255-65.

Application Data

WB

IHC