Ku80 Rabbit Recombinant mAb

生物描述

特异性

Ku80 Rabbit Recombinant mAb detects endogenous level of total Ku80.

背景

The Ku protein was originally identified as an autoantigen in patients with scleroderma-polymyositis overlap syndrome. Ku protein is a heterodimer of two subunits of 70 and 80 kDa proteins referred to as Ku70 and Ku80, respectively. As a heterodimer, Ku binds with high affinity to DNA ends, single-strand nicks and breaks, and hairpin loops independent of sequence. Ku is an abundant protein involoved in multiple cellular processes.It is required for the non-homologous end joining (NHEJ) pathway of DNA repair.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human
MW (kDa)	83kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Coffey G, et al. Nucleic Acids Res. 2000, 28(19):3793-800. [2] Victoria L Fell, et al. Mol Cell Biol. 2012, 32(1): 76-87.

Application Data

WB

IHC

IF