Leupeptin Hemisulfate

目录号：S7380 批次号：S738016

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化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C20H38N6O4.1/2H2SO4
分子量 475.59 CAS号 103476-89-7
Solubility (25°C)* 体外 DMSO 95 mg/mL (199.75 mM)
Water 95 mg/mL (199.75 mM)
Ethanol 95 mg/mL (199.75 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Leupeptin Hemisulfate是溶酶体丝氨酸蛋白酶和半胱氨酸蛋白酶可逆的抑制剂。抑制cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM)和kallikrein (Ki=19 μM)，对chymotrypsin, elastase, renin,或pepsin没有作用。
靶点
Cysteine protease [1] serine protease [1]
体外研究

Leupeptin，由不同种类的放线菌产生，强烈抑制蛋白质的水解作用。[1]

Leupeptin hemisulfate保护微管蛋白在分离过程中免受内源性蛋白质水解酶的破坏，并使微管蛋白纯度增加。[2]

Leupeptin hemisulfate能够恢复细胞悬浮培养液中高达50%的乙型肝炎表面抗原(HBsAg)的表达。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Leupeptin Hemisulfate在文献中得到引用

ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade [ Nat Commun, 2023, 14(1):4066] PubMed: 37429863
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway [ Acta Pharm Sin B, 2022, 12(6):2869-2886] PubMed: 35755273
18F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR/HK2 axis [ Theranostics, 2022, 12(14):6395-6408] PubMed: 36168616
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1 [ Theranostics, 2022, 12(11):5051-5068] PubMed: 35836803
Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription [ Cell Rep, 2022, 38(4):110302] PubMed: 35081346
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection [ Cell Biosci, 2022, 12(1):81] PubMed: 35658939
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy [ Comput Struct Biotechnol J, 2022, 20:2442-2454] PubMed: 35602976
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model [ Protein Cell, 2021, 10.1007/s13238-021-00858-3] PubMed: 34291435
ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation [ Elife, 2021, 10e62394] PubMed: 34491895
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells [ Biochem Pharmacol, 2021, 188:114562] PubMed: 33857489

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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