LRP1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	LRP1 Rabbit Recombinant mAb dectectes endogenous level of total LRP1.
背景	Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes. LRPs are constituted by an intracellular (ICD) and extracellular domain (ECD). Through its ECD, LRPs bind at least 40 different ligands ranging from lipoprotein and protease inhibitor complex to growth factors and extracellular matrix proteins. LRPs are implicated in two major physiological processes: endocytosis and regulation of signaling pathways, which are both involved in diverse biological roles including lipid metabolism, cell growth processes, degradation of proteases, and tissue invasion. The LRP1, also known as CD91 or α2macroglobulin receptor, is a multifunctional scavenger and signaling receptor that belongs to the LRP family. LRP1 is expressed abundantly on neurons, where its fundamental role is the uptake of cholesterol and fatty acids required for synapse formation. LRP1 has a dual role as a receptor which internalizes its ligands acting like a rapid cargo endocytotic cellular transporter and also as transmembrane cell signaling receptor.

特异性

LRP1 Rabbit Recombinant mAb dectectes endogenous level of total LRP1.

背景

Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes. LRPs are constituted by an intracellular (ICD) and extracellular domain (ECD). Through its ECD, LRPs bind at least 40 different ligands ranging from lipoprotein and protease inhibitor complex to growth factors and extracellular matrix proteins. LRPs are implicated in two major physiological processes: endocytosis and regulation of signaling pathways, which are both involved in diverse biological roles including lipid metabolism, cell growth processes, degradation of proteases, and tissue invasion. The LRP1, also known as CD91 or α2macroglobulin receptor, is a multifunctional scavenger and signaling receptor that belongs to the LRP family. LRP1 is expressed abundantly on neurons, where its fundamental role is the uptake of cholesterol and fatty acids required for synapse formation. LRP1 has a dual role as a receptor which internalizes its ligands acting like a rapid cargo endocytotic cellular transporter and also as transmembrane cell signaling receptor.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

85kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Spuch C, et al. Front Physiol. 2012, 3:269.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck