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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C28H25FN6O3 |
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分子量 | 512.53 | CAS号 | 603288-22-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (195.11 mM) | |
Ethanol | 2 mg/mL (3.9 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | LY2090314是一种有效的GSK-3抑制剂,作用于GSK-3α/β,IC50为1.5 nM/0.9 nM;可提高以铂类为基础的化疗方案的疗效。LY2090314对GSK3具有高选择性,对其他大多数激酶的抑制活性低。 | ||||
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体外研究 | LY2090314通过阻断ATP结合选择性抑制GSK-3的活性。LY2090314能够稳定β-连环蛋白。LY2090314单药治疗,表现出有限的疗效。LY3090314增强顺铂和卡铂对体外实体肿瘤癌细胞系的疗效。[1] |
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体内研究 | LY2090314增强顺铂和卡铂对异种移植的实体肿瘤的疗效。[1] |
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数据来源于[Data independently produced by , , Cancer Res, 2017, 77(21):5873-5885]
数据来源于[Data independently produced by , , Mol Cancer Ther, 2016, 15(7):1485-94.]
数据来源于[Data independently produced by , , Stem Cell Res, 2017, 182-187]
数据来源于[Data independently produced by , , BMC Cancer, 2018, 18(1):560]
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特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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