MAP1LC3A Rabbit Recombinant mAb

生物描述

特异性

MAP1LC3A Rabbit Recombinant mAb detects endogenous level of total MAP1LC3A.

背景

LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy. MAP1LC3A is regulated by several post-translational modifications. LC3A showed a perinuclear and nuclear localization. while LC3B was equally distributed throughout the cytoplasm and localized in the nucleolar regions. LC3C was located in the cytoplasm and strongly in the nuclei (excluding nucleoli), where it extensively co-localized with the LC3A and the Beclin-1 autophagy initiating protein.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	16kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Valente G, et al. Biomed Res Int. 2014, 2014:462658. [2] Koukourakis MI, et al. PLoS One. 2015, 10(9):e0137675.

Application Data

WB

IHC

IF